动静态心电分析系统及临床应用

目的评价"NS动静态心电分析系统"的NS-DII型产品远程心电实时采集、传输以及心电图数据回放的准确性、可靠性及临床使用价值。方法采用"NS动静态心电分析系统"的NS-DII型产品对我院100例患者进行心电数据的采集,再与已经临床注册,广泛使用的GE-3500型心电图机作为对照设备。通过两个不同设备在同一时间段,同一检测条件下对同一患者检测到的心电数据进行分析。结果 95例患者采用NS-DII型"NS动静态心电分析系统"进行的心电信号的采集和心电图数据无线实时上传及跟踪回放心电图均成功。试验中对其回放12导联心电图与GE-3500型心电图机所描记的心电图作对照分析,两个不同设备所检测到的心电数据包括心率、P-QRS-T波的时限和电压及ST段偏移等关键性技术指标上进行分析无统计学差异(p>0.05)。结论 "NS动静态心电分析系统"的NS-DII型产品是一种新型的心电监测与分析仪器,其远程心电实时采集、传输以及心电图数据回放准确、可靠。该产品适用于院内和院外心电信息的诊断和会诊。     

Chemical,Mechanical, and Durability Properties of Concrete with Local Mineral Admixtures under Sulfate Environment in Northwest China

Over the vast Northwest China, arid desert contains high concentrations of sulfate, chloride, and other chemicals in the ground water, which poses serious challenges to infrastructure construction that routinely utilizes portland cement concrete. Rapid industrialization in the region has been generating huge amounts of mineral admixtures, such as fly ash and slags from energy and metallurgical industries. These industrial by-products would turn into waste materials if not utilized in time. The present study evaluated the suitability of utilizing local mineral admixtures in significant quantities for producing quality concrete mixtures that can withstand the harsh chemical environment without compromising the essential mechanical properties. Comprehensive chemical, mechanical, and durability tests were conducted in the laboratory to characterize the properties of the local cementitious mineral admixtures, cement mortar and portland cement concrete mixtures containing these admixtures. The results from this study indicated that the sulfate resistance of concrete was effectively improved by adding local class F fly ash and slag, or by applying sulfate resistance cement to the mixtures. It is noteworthy that concrete containing local mineral admixtures exhibited much lower permeability (in terms of chloride ion penetration) than ordinary portland cement concrete while retaining the same mechanical properties; whereas concrete mixtures made with sulfate resistance cement had significantly reduced strength and much increased chloride penetration comparing to the other mixtures. Hence, the use of local mineral admixtures in Northwest China in concrete mixtures would be beneficial to the performance of concrete, as well as to the protection of environment.     

Loss of Afferent Vestibular Input Produces Central Adaptation and Increased Gain of Vestibular Prosthetic Stimulation

Implanted vestibular neurostimulators are effective in driving slow phase eye movements in monkeys and humans. Furthermore, increases in slow phase velocity and electrically evoked compound action potential (vECAP) amplitudes occur with increasing current amplitude of electrical stimulation. In intact monkeys, protracted intermittent stimulation continues to produce robust behavioral responses and preserved vECAPs. In lesioned monkeys, shorter duration studies show preserved but with somewhat lower or higher velocity behavioral responses. It has been proposed that such changes are due to central adaptive changes in the electrically elicited vestibulo-ocular reflex (VOR). It is equally possible that these differences are due to changes in the vestibular periphery in response to activation of the vestibular efferent system. In order to investigate the site of adaptive change in response to electrical stimulation, we performed transtympanic gentamicin perfusions to induce rapid changes in vestibular input in monkeys with long-standing stably functioning vestibular neurostimulators, disambiguating the effects of implantation from the effects of ototoxic lesion. Gentamicin injection was effective in producing a large reduction in natural VOR only when it was performed in the non-implanted ear, suggesting that the implanted ear contributed little to the natural rotational response before injection. Injection of the implanted ear produced a reduction in the vECAP responses in that ear, suggesting that the intact hair cells in the non-functional ipsilateral ear were successfully lesioned by gentamicin, reducing the efficacy of stimulation in that ear. Despite this, injection of both ears produced central plastic changes that resulted in a dramatically increased slow phase velocity nystagmus elicited by electrical stimulation. These results suggest that loss of vestibular afferent activity, and a concurrent loss of electrically elicited vestibular input, produces an increase in the efficacy of a vestibular neurostimulator by eliciting centrally adapted behavioral responses without concurrent adaptive increase of galvanic afferent activation in the periphery.     

Epstein-Barr virus gene polymorphism in different parts of the same nasopharyngeal carcinoma patient

In most previous studies, comparisons of Epstein-Barr virus (EBV) gene polymorphisms and genotypes were made between strains from tumors and normal throat washings (TWs) from different individuals. However, it remains controversial whether different EBV subtypes are present in different parts of the same NPC patient. In order to address this question, in this study, we compared the genotypes in sets of paired throat washings (TW) and paraffin-embedded tissues of 20 patients with nasopharyngeal carcinoma (NPC), and we found the same genotype in throat washings (TWs) and tumor cells from the same individual in most cases. The subtypes of EBER and EBNA1 genes were furthermore sequenced, and identical EBV strains were identified in tumor tissues and TWs. In conclusion, different sites of the same individual are infected by the same EBV strains, except for a few differences in occasional cases, suggesting that the EBV subtype detected in throat washings is a reasonable guide to the subtype present in the carcinoma tissue.     

An unusual case of prenatal diagnosis of right coronary artery to right ventricle fistula with HD-flow render mode and spatiotemporal image correlation (STIC)

Coronary artery fistula is rare in prenatal diagnosis. We have reported a case diagnosis of coronary artery fistula by using high-definition flow (HD-flow) render mode and spatiotemporal image correlation (STIC), and then evaluated the postnatal outcomes in our hospital.     

《药物分析》课程本科教学改革和思考

目的　分析《药物分析》课程在当今药学本科教育培养过程中的现状，探索《药物分析》课程在新时代药学教育背景下的教学改革与创新，构建符合药学培养要求、满足社会市场需要的复合型药学人才培养模式。方法　第一阶段，开展教学改革的建议和需求调查；第二阶段，开展《药物分析》课程改革探索与实践；第三阶段，教学效果评价。结果　需求调查显示《药物分析》课程的教学内容、课程设计、教学手段亟须进一步优化和拓展。结论　该课程通过调整教学内容、拓展教学手段、创新多元化实践教学、融入"课程思政"建设等，激发了学生的学习兴趣和创新精神，强化了学生理论素养和实践能力，培养了其国际化视野和崇高的职业道德。